Adult stem cells to treat multiple sclerosis

Description:Neural stem cells NSCs — glial cells Haffernan et al, 90 Clinical human model The study involved the designing of CPP sequence that selectively transduced human glial cells excluding nonglial cell types , and conducted preliminary screens of purified, recombinant CPPs with immature and matured human oligodendrocytes and astrocytes and two nonglial cell types to treat MS. Embryonic stem cells derived NSCs Payne et al, 91 Preclinical mouse model The study evaluated the therapeutic potential of NSCs derived from ES cells by two different neural differentiation protocols that utilized adherent culture conditions and compared their effect with primary NSCs derived from the subventricular zone SVZ. Hematopoietic stem cells HSCs Fassas and Kazis, 41 Clinical Phase I and II studies in human The study was based on concept of immune ablation by high-dose therapy and reconstitution of normal immunity from transplant-derived lymphocyte progenitors. Neural precursor stem cells NPSCs Donega et al, 93 Preclinical mouse model The study involved injecting NPSCs in mice model of experimental autoimmune encephalomyelitis EAE , via iv and icv route of administration, with chronic CNS inflammatory demyelination, and envisage the systemic stem cell delivery as a valuable technique for the selective targeting of the inflamed brain in regenerative neurology. Peripheral blood stem cells were derived by leukapheresis after mobilized with granulocyte colony-stimulating factor.

Views: 8873 Date: 2018-09-09 Favorited: 55